王慧菁的個人資料 - 清華大學生命科學院

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姓名	王慧菁
傳真	03-5715934
個人網站	https://sites.google.com/site/lilywangslab/

類別	專任師資
職稱	副教授
單位別	分子與細胞生物研究所 / 學士班 / 醫科系
授課領域	細胞生物學、腫瘤病毒學
研究專長	細胞生物學、腫瘤病毒學

期刊論文一覽
年度	著作	著作人
2021	Bhattacharjee MJ, Lin JJ, Chang CY, Chiou YT, Li TN, Tai CW, Shiu TF, Chen CA, Chou CY, Chakraborty P, Tseng YY, Wang LH, Li WH,2021,Identifying primate ACE2 variants that confer resistance to SARS-CoV-2,Molecular Biology and Evolution, (SCI)	王慧菁
2021	Wu YH, Yang Y, Chen CH, Hsiao CJ, Li TN, Liao KJ, Watashi K, Chen BS, Wang LH,2021,Aerobic glycolysis supports hepatitis B virus biosynthesis through interaction between viral surface antigen and pyruvate kinase isoform M2,PLOS Pathogens, (SCI)	王慧菁
2021	Chen CH, Lu F, Yang WJ, Yang PE, Chen WM, Kang ST, Huang YS, Kao YC, Feng CT, Chang PC, Wang T, Hsieh CA, Lin YC, Huang JYJ, Wang LH,2021,A Novel Platform for Discovery of Differentially Expressed microRNAs in Patients with Repeated Implantation Failure,Fertility and Sterility*, (SCI)	王慧菁
2021	Kuo CJ, Chao TL, Kao HC, Tsai YM, Liu YK, Wang LH, Hsieh MC, Chang SY, Liang PH,2021,Kinetic characterization and inhibitor screening for the proteases leading to identification of drugs against SARS-CoV-2.,Antimicrobial Agents and Chemotherapy, (SCI)	王慧菁
2020	Kuo PH, Teng YH, Cin AL, Han W, Huang PW, Wang LH, Chou YT, Yang JL, Tseng YL, Kao M, Chang MD,2020,Heparan sulfate targeting strategy for enhancing liposomal drug accumulation and facilitating deep distribution in tumors.,Drug Delivery,27,1,pp542-555 (SCI)	王慧菁
2020	Chen PL, Tzeng TT, Hu AY, Wang LH, Lee MS,2020,Development and Evaluation of Vero Cell-Derived Master Donor Viruses for Influenza Pandemic Preparedness,Vaccines,8,4,ppE626- (SCI)	王慧菁
2020	Chang S, Wang LH, Chen BS,2020,Investigating Core Signaling Pathways of Hepatitis B Virus Pathogenesis for Biomarkers Identification and Drug Discovery via Systems Biology and Deep Learning Method ,	王慧菁
2020	Fu TK, Kuo PH, Lu YC, Lin HN, Wang LH, Lin YC, Kao YC, Lai HM, Chang MD,2020,Cell Penetrating Peptide as a High Safety Anti-Inflammation Ingredient for Cosmetic Applications,Biomolecules,10,1,pp101- (SCI)	王慧菁
2019	Yeh SJ, Chang CA, Li CW, Wang LH, Chen BS,2019,Comparing progression molecular mechanisms between lung adenocarcinoma and lung squamous cell carcinoma based on genetic and epigenetic networks: big data mining and genome-wide systems identification,Oncotarget,10,38,pp3760-3806 (SCI)	王慧菁
2019	Wong SW, Yeh SJ, Li CW, Wang LH, Chen BS,2019,Investigation mechanisms between normal, developing and regenerating livers for regenerative liver drug design,Regenerative Medicine,14,5,pp359-387 (SCI)	王慧菁
2018	Li TN, Wu YJ, Tsai HW, Sun CP, Wu YH, Wu HL, Pei YN, Lu KY, Yen TT, Chang CW, Chan HL, Tao MH, Liou JY, Chang MD, Su IJ, Wang LH,2018,Intrahepatic hepatitis B virus large surface antigen induces hepatocyte hyperploidy via failure of cytokinesis,Journal of Pathology,245,4,pp502-513 (SCI)	王慧菁
2017	Hung LC, Jiang I, Chen CJ, Lu JY, Hsieh YF, Kuo PH, Hung YL, Wang LH, Chang MD, Sue SC. ,2017,Heparin-Promoted Cellular Uptake of the Cell-Penetrating Glycosaminoglycan Binding Peptide, GBPECP, Depends on a Single Tryptophan,ACS Chemical Biology,12,2,pp398-406 (SCI)	王慧菁
2016	Yen TT, Yang A, Chiu WT, Li TN, Wang LH, Wu YH, Wang HC, Chen L, Wang WC, Huang W, Chang CW, Chang MD, Shen MR, Su IJ, Wang LH,2016,Hepatitis B virus PreS2-mutant large surface antigen activates store-operated calcium entry and promotes chromosome instability,Oncotarget,7,17,pp23346-23360 (SCI)	王慧菁
2015	Christian F. Nielsen, Diana Huttner, Anna H. Bizard, Seiki Hirano, Tian-Neng Li, Timea Palmai-Pallag, Victoria A. Bjerregaard, Ying Liu, Erich A. Nigg, Lily Hui-Ching Wang & Ian D. Hickson,2015,PICH promotes sister chromatid disjunction and co-operates with topoisomerase II in mitosis,Nature Communications, (SCI)	王慧菁
2015	Yi-Hsuan Hsieh, Yu-Ying Chang, Ih-Jen Su, Chia-Jui Yen, Yi-Ru Liu, Ren-Jei Liu, Wen-Chuan Hsieh, Hung-Wen Tsai, Lily Hui-Ching Wang, Wenya Huang,2015,Hepatitis B virus pre-S2 mutant large surface protein inhibits DNA double strand break repair and leads to genome instability in hepatocarcinogenesis,Journal of Pathology, (SCI)	王慧菁
2015	Chen CJ, Shih CH, Chang YJ, Hong SJ, Li TN, Wang LH, Chen L. ,2015,SH2B1 and IRSp53 Proteins Promote the Formation of Dendrites and Dendritic Branches,Journal of Biological Chemistry,290,pp6010-6021 (SCI)	王慧菁
2015	Lyu-Han Wang, Chia-Jui Yen, Tian-Neng Li, Sabine Elowe, Wen-Ching Wang, Lily Hui-Ching Wang,2015,Sgo1 is a potential therapeutic target for hepatocellular carcinoma,Oncotarget,6,4,pp2023-2033 (SCI)	王慧菁
2015	Szu-Ting Lin, Eugenie Wong Soon May, Jo-Fan Chang, Ren-Yu Hu, Lily Hui-Ching Wang, Hong-Lin Chan ,2015,PGRMC1 contributes to doxorubicin-induced chemoresistance in MES-SA uterine sarcoma,Cellular and Molecular Life Sciences, (SCI)	王慧菁
2014	Ih-Jen Su, Lily Hui-Ching Wang, Wen-Chuan Hsieh, Han-Chieh Wu, Chiao-Fang Teng, Hung-Wen Tsai, Wenya Huang,2014,The emerging role of hepatitis B virus Pre-S2 deletion mutant proteins in HBV tumorigenesis,Journal of biomedical science,21,1,pp98- (SCI)	王慧菁
2014	Kung-Chao Chang, Yao Chang, Lily Hui-Ching Wang, Hung-Wen Tsai, Wenya Huang, Ih-Jen Su,2014,Pathogenesis of virus-associated human cancers: Epstein–Barr virus and hepatitis B virus as two examples,Journal of the Formosan Medical Association,113,9,pp581-590 (SCI)	王慧菁
2014	Shin-Yi Du, Hung-Jung Wang, Hsin-Hung Cheng, Sheng-De Chen, Lily Hui-Ching Wang, Wen-Ching Wang,2014,Cholesterol glucosylation by Helicobacter pylori delays internalization and arrests phagosome maturation in macrophages,Journal of Microbiology, Immunology and Infection, (SCI)	王慧菁
2014	Han-Chieh Wu, Hung-Wen Tsai, Chiao-Fang Teng, Wen-Chuan Hsieh, Yi-Chi Lin, Lily Hui-Ching Wang, Quan Yuan, Ih-Jen Su,2014,Ground glass hepatocytes co-expressing hepatitis B virus X protein and surface antigens exhibit enhanced oncogenic effects and tumorigenesis,Human Pathology, (SCI)	王慧菁
2013	Biebricher A., Hirano S., Enzlin J., Wiechens N., Streicher W., Liu Y., Huttner D., Wang LH., Nigg EA., Owen-Hughes T., Peterman E., Wuite G., and Hickson I.,2013,PICH: a DNA Translocase Specially Adapted for Processing Anaphase Bridge DNA,Molecular Cell, (SCI)	王慧菁
2013	Chang KC, Chang Y, Wang LH, Tsai HW, Huang W, Su IJ,2013,Pathogenesis of viruses-associated human cancers: Epstein-Barr virus and hepatitis B virus as two examples,J Formos Med Assoc, (SCI)	王慧菁
2013	Yi-Ru Liu, Sheng-Yen Huang, Jen-Yang Chen, and Lily Hui-Ching Wang,2013,Microtubule depolymerization activates the Epstein-Barr virus lytic cycle through protein kinase C pathways in nasopharyngeal carcinoma cells,Journal of General Virology, (SCI)	王慧菁
2012	Yu GY, He G, Li CY, Tang M, Grivennikov S, Tsai WT, Wu MS, Hsu CW, Tsai Y, Wang LH, Karin M,2012,Hepatic Expression of HCV RNA-Dependent RNA Polymerase Triggers Innate Immune Signaling and Cytokine Production,Molecular Cell, (SCI)	王慧菁
2012	Hung-Ju Shih, Kang-Lin Chu, Meng-Hsun Wu, Pei-Hsuan Wu, Wei-Wen Chang, Jan-Show Chu, Lily Hui-Ching Wang, Hideki Takeuchi, Toru Ouchi, and Hsin-Ling Hsu,2012,The involvement of MCT-1 oncoprotein in inducing mitotic catastrophe and nuclear abnormalities,Cell Cycle,11,5,pp934-52 (SCI)	王慧菁
2012	Wang LH, Huang W, Lai MD, Su IJ,2012,Aberrant cyclin A expression and centrosome overduplication induced by hepatitis B virus Pre-S2 mutants and its implication in hepatocarcinogenesis,Carcinogenesis, (SCI)	王慧菁
2011	Hung JH, Teng YN, Wang LH, Su IJ, Wang CC, Huang W, Lee KH, Lu KY, Wang LH,2011,Induction of bcl-2 expression by hepatitis B virus pre-s2 mutant large surface protein resistance to 5-Fluorouracil treatment in huh-7 cells,PLoS One,6,12,ppe28977- (SCI)	王慧菁
2010	Hubner, N.C., Wang, L.H.C., Kaulich, M., Descombes, P., Poser, I. and Nigg, E. A. ,2010,Re-examination of siRNA specificity questions role of PICH and Tao1 in the spindle checkpoint and identifies Mad2 as a sensitive target for small RNAs,Chromosoma,119,2,pp149-165 (SCI)	王慧菁
2010	Wang L HC, Mayer B, Stemmann O, and Nigg EA.,2010,Centromere DNA decatenation depends on separase activation and is required for mammalian cell division,Journal of Cell Science*,123,5,pp806-813	王慧菁
2008	2010,Su IJ, Wang HC, Wu HC, Huang WY. Ground glass hepatocytes contain pre-S mutants and represent preneoplastic lesions in chronic hepatitis B virus infection. Review Article. J Gastroenterol Hepatol. 2008 23(8 Pt 1):1169-74,J Gastroenterol Hepatol.,23,pp1169-1174	王慧菁
2008	2008,Wang L HC, Schwarzbraun T, Speicher MR, Nigg EA. Persistence of DNA threads in human anaphase cells suggests late completion of sister chromatid decatenation. Chromosoma 2008, 117(2):123-35,Chromosoma,117,pp123-135	王慧菁
2007	2007,Hsieh YH, Su IJ, Wang HC, Tsai JH, Huang YJ, Chang WW, Lai MD, Lei HY, Huang W. Hepatitis B virus pre-S2 mutant surface antigen induces degradation of cyclindependent kinase inhibitor p27Kip1 through c-Jun activation domain-binding protein 1. Molecular Cancer Research 2007 10: 2063-72,Molecular Cancer Research,10,pp2063-2072	王慧菁
2006	2006,Wang HC, Lai MD, Huang W, Su IJ. Hepatitis B Virus Pre-S Mutants, ER stress and Hepatocarcinogenesis. Review Article. Cancer Science 2006, 97:683-688,Cancer Science,97,pp683-688	王慧菁
2005	Wang HC, Chang WT, Chang WW, Wu HC, Huang W, Lei HY, Lai MD, Fausto N, Su IJ,2005,Wang HC, Chang WT, Chang WW, Wu HC, Huang W, Lei HY, Lai MD, Fausto N, Su IJ: Hepatitis B virus pre-S2 mutant upregulates cyclin A expression and induces nodular proliferation of hepatocytes. Hepatology 2005, 41:761-770,Hepatology,41,pp761-770	王慧菁
2005	Chuang HC, Lay JD, Hsieh WC, Wang HC, Chang Y, Chuang SE, Su IJ.,2005,Chuang HC, Lay JD, Hsieh WC, Wang HC, Chang Y, Chuang SE, Su IJ. Epstein-Barr virus LMP1 inhibits the expression of SAP gene and Upregulates Th1 cytokines in the pathogenesis of hemophagocytic syndrome. Blood 2005, 106:3090-3096,Blood,106,pp3090-3096	王慧菁

個人研究一覽
標題	日期	附件檔案
Research Interests	2010年10月14日	檔案下載

專利一覽
年度	專利類別	專利名稱	西元年月	專利人
2017	其他	METHOD USING HEAT SHOCK PROTEIN INHIBITOR FOR TREATING HEPATITIS AND HEPATOMA	2016-06-00	王慧菁 / 顏廷忠, 黃麗蓉, 王慧菁
2016	其他	熱休克蛋白抑制劑用於製備治療B型肝炎或肝癌之醫藥組合物的用途	2016-06-00	王慧菁 / 顏廷忠, 黃麗蓉, 王慧菁

校外榮譽一覽
得獎年度	獎項名稱	頒獎單位
108	財團法人肝病防治學術基金會- 25週年研究獎助	財團法人肝病防治學術基金會
105	吳健雄學術基金會台灣女科學家新秀獎	吳健雄學術基金會

學歷一覽
學校名稱	國別	系所	學位	起迄年月
成功大學	台灣	基礎醫學研究所	博士	1998年09月 ~ 2004年06月
成功大學	中華民國	生物系	學士	1993年09月 ~ 1997年06月

服務機關	職稱	起迄年月
National Tsing Hua University	Assistant Professor	2010年08月 ~
Biozentrum, University of Basel, Basel, Switzerland	Project Leader	2009年08月 ~ 2010年07月
Department of Cell Biology, Max-Planck Institute of Biochemistry, Martinsried	Postdoc	2006年06月 ~ 2009年08月
Division of Clinical Research, National Health Research Institutes, Tainan, Taiwan	Postdoc	2004年07月 ~ 2006年05月
Department of Pathology, University of Washington, Seattle, Washington, USA	Research Scientist	2001年06月 ~ 2001年09月

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清華大學生命科學院