湯學成的個人資料 - 清華大學生命科學院

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姓名	湯學成
個人網站	http://www.3d-histology.com
職銜	American Gastroenterological Association Fellow

類別	專任師資
職稱	教授
單位別	生物科技研究所 / 學士班 / 醫科系
授課領域	生物醫學工程
研究專長	三維醫學組織影像
討論區	討論區連結

期刊論文一覽
年度	著作	著作人
2021	Tien YW, Chien HJ, Chiang TC, Chung MH, Lee CY, Peng SJ, Chen CC, Chou YH, Hsiao FT, Jeng YM, and Tang SC*. Local islet remodeling associated with duct lesion-islet complex in adult human pancreas. Diabetologia, 2021. In press. (IF: 10.122; 9/145 ENDOCRINOLOGY & METABOLISM),	湯學成
2021	Chen CC, Peng SJ, Wu PY, Chien HJ, Lee CY, Chung MH, and Tang SC*. Heterogeneity and neurovascular integration of intraportally transplanted islets revealed by 3-D mouse liver histology. American Journal of Physiology - Endocrinology and Metabolism, 320:E1007-E1019, 2021. (IF: 4.310; 15/81 PHYSIOLOGY),	湯學成
2021	Campbell-Thompson M and Tang SC. Pancreas optical clearing and 3-D microscopy in health and diabetes. Frontiers in Endocrinology, 12: Article 644826, 2021. Review. https://doi.org/10.3389/fendo.2021.644826 (IF: 5.555; 32/145 ENDOCRINOLOGY & METABOLISM),	湯學成
2020	Lin CY and Tang SC*. Nature Reviews Nephrology, Cover image 2020 Jan-Dec, all twelve issues: In-depth fluorescence imaging of renal blood vessels. Winner of 2020 Nature Reviews cover image competition. www.nature.com/collections/fifigibgci ; www.nature.com/nrneph/volumes/16/issues/1,	湯學成
2019	Shen CN, Goh KS, Huang CR, Chiang TC, Lee CY, Jeng YM, Peng SJ, Chien HJ, Chung MH, Chou YH, Hsieh CC, Kulkarni S, Pasricha PJ, Tien YW, and Tang SC. Lymphatic vessel remodeling and invasion in pancreatic cancer progression. EBioMedicine, 47:98-113, 2019. (IF: 8.143; 17/140 MEDICINE, RESEARCH & EXPERIMENTAL),	湯學成
2019	Chien HJ, Chiang TC, Peng SJ, Chung MH, Chou YH, Lee CY, Jeng YM, Tien YW, and Tang SC. Human pancreatic afferent and efferent nerves: mapping and 3-D illustration of exocrine, endocrine, and adipose innervation. American Journal of Physiology - Gastrointestinal and Liver Physiology, 317: G694-G706, 2019. (IF: 4.052; 20/81 PHYSIOLOGY),	湯學成
2018	Tang SC, Shen CN, Lin PY, Peng SJ, Chien HJ, Chou YH, Chamberlain CE, and Pasricha PJ. Pancreatic neuro-insular network in young mice revealed by 3-D panoramic histology. Diabetologia. 61:158-167, 2018. Back-to-back featured article. (IF: 10.122; 9/145 ENDOCRINOLOGY & METABOLISM),	湯學成
2018	Tang SC*, Baeyens L, Shen CN, Peng SJ, Chien HJ, Scheel DW, Chamberlain CE, and German MS. Human pancreatic neuro-insular network in health and fatty infiltration. Diabetologia, 61:168-181, 2018. Back-to-back featured article. (IF: 10.122; 9/145 ENDOCRINOLOGY & METABOLISM),	湯學成
2018	Tang SC, Jessup CF, and Campbell-Thompson M*. The role of accessory cells in islet homeostasis. Current Diabetes Reports. 18(11):117, 2018. (IF: 4.810; 46/145 ENDOCRINOLOGY & METABOLISM),	湯學成
2018	Peng SJ and Tang SC*. Nature Reviews Endocrinology, Cover image 2019 Jan-Dec, all twelve issues: Peri-islet vasodilation and lymphocytic infiltration in experimental type 1 diabetes mellitus. Winner of 2018 Nature Reviews cover image competition (https://www.nature.com/nrendo/volumes/15/issues/1),	湯學成
2017	Tang SC, Peng SJ, Baeyens L and German MS. Nature Reviews Endocrinology, Cover image 2017 Jan-Dec, all twelve issues: Human pancreatic microenvironment in type 2 diabetes mellitus. http://www.nature.com/nrendo/journal/v13/n1/index.html,	湯學成
2017	Kulkarni S, Micci MA, Leser J, Shin C, Tang SC, Fu YY, Liu L, Li Q, Saha M, Li C, Enikolopov G, Becker L, Rakhilin N, Anderson M, Shen X, Dong X, Butte MJ, Song H, Southard-Smith EM, Kapur RP, Bogunovic M, Pasricha PJ. Adult enteric nervous system in health is maintained by a dynamic balance between neuronal apoptosis and neurogenesis. Proc Natl Acad Sci USA,114: E3709-E3718, 2017. (Contribution: application of 3-D histology to investigate enteric nervous system),	湯學成
2016	Chien HJ, Peng SJ, Hua TE, Kuo CH, Juang JH, and Tang SC*. 3-D imaging of islets in obesity: formation of the islet-duct complex and neurovascular remodeling in young hyperphagic mice. International Journal of Obesity, 40: 685-697, 2016. (IF: 4.419; 29/143 ENDOCRINOLOGY & METABOLISM),	湯學成
2016	Lin PY, Peng SJ, Shen CN, Pasricha PJ, and Tang SC. PanIN-associated pericyte, glial, and islet remodeling in mice revealed by 3-D pancreatic duct lesion histology. American Journal of Physiology - Gastrointestinal and Liver Physiology, 311: G412–G422, 2016. (IF: 4.052; 20/81 PHYSIOLOGY),	湯學成
2015	Liu YA, Chung YC, Shen MY, Pan ST, Kuo CW, Peng SJ, Pasricha PJ, and Tang SC*. Perivascular interstitial cells of Cajal in human colon. Cellular and Molecular Gastroenterology and Hepatology. 1(1):102-119, 2015. (IF: 9.225; 13/92 GASTROENTEROLOGY & HEPATOLOGY),	湯學成
2015	Peng SJ and Tang SC. Nature Reviews Nephrology, Cover image 2015 Jan-Dec, all twelve issues: Projection of mouse renal pericytes and their association with glomeruli. http://www.nature.com/nrneph/journal/v11/n12/index.html,	湯學成
2015	Juang JH, Kuo CH, Peng SJ, and Tang SC*. 3-D imaging reveals participation of donor islet Schwann cells and pericytes in islet transplantation and graft neurovascular regeneration. EBioMedicine, 2:109-119, 2015. Cover image of February issue. (IF: 8.143; 17/140 MEDICINE, RESEARCH & EXPERIMENTAL),	湯學成
2014	Hsu CT and Tang SC. Nature Reviews Endocrinology, Cover image 2014 Jan-Dec, all twelve issues: Mouse islet Schwann cell network. http://www.nature.com/nrendo/journal/v10/n1/index.html,	湯學成
2014	Juang JH, Peng SJ, Kuo CH, and Tang SC*. Three-dimensional islet graft histology: panoramic imaging of neural plasticity in sympathetic reinnervation of transplanted islets under the kidney capsule. American Journal of Physiology - Endocrinology and Metabolism, 306:E559-E570, 2014. (IF: 4.310; 15/81 PHYSIOLOGY),	湯學成
2014	Tang SC*, Peng SJ, and Chien HJ. Imaging of the islet neural network. Diabetes, Obesity and Metabolism, 16 (Suppl. 1): 77-86, 2014. (IF: 6.577; 21/145 ENDOCRINOLOGY & METABOLISM),	湯學成
2013	Fu YY, Peng SJ, Lin HY, Pasricha PJ, and Tang SC. 3-D imaging and illustration of mouse intestinal neurovascular complex. American Journal of Physiology - Gastrointestinal and Liver Physiology. 304:G1-G11, 2013 (Cover image),	湯學成
2013	Liu YA, Chung YC, Pan ST, Shen MY, Hou YC, Peng SJ, Pasricha PJ, and Tang SC. 3-D imaging, illustration, and quantitation of enteric glial network in transparent human colon mucosa. Neurogastroenterology & Motility. 25:e324-338, 2013,	湯學成
2013	Tang SC*, Chiu YC, Hsu CT, Peng SJ, and Fu YY. Plasticity of Schwann cells and pericytes in response to islet injury in mice. Diabetologia. 56:2424-2434, 2013. Cover image of November issue. (IF: 10.122; 9/145 ENDOCRINOLOGY & METABOLISM),	湯學成
2013	Hua TE, Yang TL, Yang WC, Liu KJ, and Tang SC. 3-D neurohistology of transparent tongue in health and injury with optical clearing. Frontiers in Neuroanatomy, 7:36 (10 pages), 2013,	湯學成
2012	Liu YA, Chung YC, Pan ST, Hou YC, Peng SJ, Pasricha PJ, and Tang SC. 3-D illustration of network orientations of interstitial cells of Cajal subgroups in human colon as revealed by deep-tissue imaging with optical clearing. American Journal of Physiology - Gastrointestinal and Liver Physiology. 302:G1099-G1110, 2012 (selected as featured article on the May 15 issue: "3-D illustration of ICC network orientations") ,	湯學成
2012	Chiu YC, Hua TE, Fu YY, Pasricha PJ, and Tang SC*. 3-D imaging and illustration of the perfusive mouse islet sympathetic innervation and its remodelling in injury. Diabetologia. 55:3252-3261, 2012. (IF: 10.122; 9/145 ENDOCRINOLOGY & METABOLISM) Selected as featured article and accompanied with a commentary “Islet nerves in focus – defining their neurobiological and clinical role” 55:3152-3154, 2012,	湯學成
2011	Liu YA, Chen Y, Chiang AS, Peng JS, Pasricha PJ, and Tang SC. Optical clearing improves the imaging depth and signal-to-noise ratio for digital analysis and 3-dimensional projection of the human enteric nervous system. Neurogastroenterology & Motility. 23:e446-457, 2011 (This article is highlighted by Nature Reviews Gastroenterology & Hepatology 8, 600: Improving 3D imaging of the enteric nervous system),	湯學成
2011	Tseng SJ, Chen ZH, and Tang SC*. Application of heparinized cellulose matrices for substrate-mediated bFGF peptide and transgene delivery to stimulate cellular proliferation. Cellulose. 18: p95-104, 2011. (IF: 5.044; 1/22 MATERIALS SCIENCE, PAPER & WOOD),	湯學成
2010	Fu YY and Tang SC*. At the movies: 3-dimensional technology and gastrointestinal histology. Gastroenterology, 139(4): p1100-1105, 2010. (IF: 22.682; 4/92 GASTROENTEROLOGY & HEPATOLOGY),	湯學成
2010	Tang SC, Fu YY, Lo WF, Hua TE, and Tuan HY*. Vascular labeling of luminescent gold nanorods enables 3-D microscopy of mouse intestinal capillaries. ACS Nano, 4(10):6278-84, 2010. (IF: 15.881; 11/107 NANOSCIENCE & NANOTECHNOLOGY),	湯學成
2010	Fu YY and Tang SC. Optical clearing facilitates integrated 3D visualization of mouse ileal microstructure and vascular network with high definition. Microvascular Research, 80(3):512-21, 2010,	湯學成
2010	Fu YY, Lu CH, Lin CW, Juang JH, Enikolopov G, Sibley E, Chiang AS, Tang SC. Three-dimensional optical method for integrated visualization of mouse islet microstructure and vascular network with subcellular-level resolution. Journal of Biomedical Optics. 15(4), Article Number: 046018 (9 pages), 2010,	湯學成
2009	Fu YY, Lin CW, Enikolopov G, Sibley E, Chiang AS, and Tang SC*. Microtome-free 3-dimensional confocal imaging method for visualization of mouse intestine with subcellular-level resolution. Gastroenterology. 137(2): p453-465, 2009. (IF: 22.682; 4/92 GASTROENTEROLOGY & HEPATOLOGY),	湯學成
2009	Tseng SJ, Lee YH, Chen ZH, Lin HH, Lin CY, and Tang SC. Integration of optical clearing and optical sectioning microscopy for three dimensional imaging of natural biomaterial scaffolds in thin sections. Journal of Biomedical Optics. 14(4), Article Number: 044004 (9 pages), 2009,	湯學成
2008	Wang ZH, Chien WC, Yue TW and Tang SC. Application of heparinized cellulose affinity membranes in recombinant adeno-associated virus serotype 2 binding and delivery. Journal of Membrane Science. 310: p141-148, 2008,	湯學成
2008	Chen CA, Lo CK, Lin BL, Sibley E, and Tang SC. Application of doxorubicin-induced rAAV2-p53 gene delivery in combined chemotherapy and gene therapy for hepatocellular carcinoma. Cancer Biology & Therapy. 7(2): p303-309, 2008,	湯學成
2008	Tseng SJ, Chuang CJ and Tang SC. Electrostatic immobilization of DNA polyplexes on small intestinal submucosa for tissue substrate-mediated transfection. Acta Biomaterialia. 4: p799-807, 2008,	湯學成
2008	Fu YY, Sibley E, and Tang SC. Transient cytochalasin-D treatment induces apically administrated rAAV2 across tight junctions for transduction of enterocytes. Journal of General Virology. 89: p3304-3308, 2008,	湯學成
2008	Li H, Shih WH, Shih WY, Chen L, Tseng SJ and Tang SC. Transfection of aqueous CdS quantum dots using polyethylenimine. Nanotechnology. 19, Article Number: 475101 (8 pages), 2008,	湯學成
2007	Yue TW, Chien WC, Tseng SJ and Tang SC. EDC/NHS-mediated heparinization of small intestinal submucosa for recombinant adeno-associated virus serotype 2 binding and transduction. Biomaterials. 28(14): p2350-2357, 2007,	湯學成
2007	Tseng SJ and Tang SC. Development of poly(amino ester glycol urethane)/siRNA polyplexes for gene silencing. Bioconjugate Chemistry. 18(5): p1383-1390, 2007,	湯學成
2007	Tseng SJ and Tang SC. Synthesis and characterization of a novel transfection reagent poly(amino ester glycol urethane). Biomacromolecules. 8(1): p50-58, 2007,	湯學成

校外榮譽一覽
得獎年度	獎項名稱	頒獎單位
9	American Gastroenterological Association (AGA) Fellow
8	Winner of Nature Reviews Cover Image Competition (Endocrinology 2014, 2017, and 2019; Nephrology 2015)
7	American Diabetes Association, Member, 2012
6	Scientific Paper Award by Far Eastern Y. Z. Hsu Science and Technology Memorial Foundation, Taiwan (category: biomedical technology), 2011
5	Academic Sinica Junior Research Investigator Award (category: life sciences), 2011
4	American Physiological Society, Member, 2011
3	Young Investigator Award, National Science Council, 2009
2	American Gastroenterological Association (AGA), International Affiliate Member, 2005
1	American Gastroenterological Association (AGA), Trainee Member, 2004

學歷一覽
學校名稱	國別	系所	學位	起迄年月
Stanford University School of Medicine	USA	Pediatric Gastroenterology	Postdoctoral Fellow	2004年01月 ~ 2004年12月
Georgia Institute of Technology	USA	Chemical & Biomolecular Engineering	Ph.D.	1998年09月 ~ 2003年12月
National Cheng Kung University, Taiwan		Chemical Engineering	M.S.	1992年09月 ~ 1994年05月
National Cheng Kung University, Taiwan		Chemical Engineering	B.S.	1988年09月 ~ 1992年05月

標題	日期	附件檔案
Research featured in NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY, 2017 Jan. Editorial: covering gastroenterology and hepatology. Lymphatic vessel system in mouse intestine. http://www.nature.com/nrgastro/journal/v14/n1/pdf/nrgastro.2016.188.pdf
Research featured in NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY, 2011 Nov. Neurogastroenterology: Improving 3D imaging of the enteric nervous system. http://www.nature.com/nrgastro/journal/v8/n11/full/nrgastro.2011.167.html

服務機關	職稱	部門/系所	起迄年月
National Tsing Hua University, Taiwan	Professor	Institute of Biotechnology	2012年02月 ~
National Tsing Hua University, Taiwan	Professor	Department of Medical Science	2012年02月 ~
National Tsing Hua University, Taiwan	Professor (joint appointment)	Chemical Engineering	2012年02月 ~
National Tsing Hua University, Taiwan	Professor	Chemical Engineering	2011年08月 ~ 2012年01月
National Tsing Hua University, Taiwan	Associate Professor	Chemical Engineering	2008年08月 ~ 2011年07月
National Tsing Hua University, Taiwan	Assistant Professor	Chemical Engineering	2005年08月 ~ 2008年07月
Nanyang Technological University, Singapore	Assistant Professor	Chemical & Biomolecular Engineering	2005年01月 ~ 2005年07月

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清華大學生命科學院